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Dr. Ryan Russell's Publications

Selected Publications

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An antibody for analysis of autophagy induction

Tian WS, Alsaadi RM, Guo ZH, Kalinina A, Carrier M, Tremblay ME, Lacoste B, Lagace D & Russell RC 

Nature Methods (2019); 2020 Feb; 17(2):232-239; PMID: 31768061

Iron overload inhibits late stage autophagic flux leading to insulin resistance

Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G

EMBO Rep. 2019 Oct 4; 20(10):e47911; PMID: 31441223

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant

Alsaadi RM, Losier TT, Tian WS, Jackson A, Guo ZH, Rubinsztein DC, Russell RC

EMBO reports. 2019 May 24; e46885; PMID: 31267703

AMPK promotes xenophagy through priming of autophagic kinases upon detection of bacterial outer membrane vesicles

Losier TT, Akuma M, McKee-Muir OC, LeBlond ND, Alsaadi RM, Suk YJ, Guo ZH, Reshke R, Sad S, Campbell-Valois FX, Gibbings DJ, Fullerton MD, Russell RC

Cell Rep. 2019 Feb 19;26(8):2150-2165. PMID: 30784596

mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease.

Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG.

Science Signaling. 2017 Dec 19;10(510). PMID: 29259100  

Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.

Guo H, Chitiprolu M, Roncevic L, Javalet C, Hemming FJ, Trung MT, Meng L, Latreille E, Tanese de Souza C, McCulloch D, Baldwin RM, Auer R, Côté J, Russell RC, Sadoul R, Gibbings D.

Developmental Cell. 2017 Dec 18;43(6):716-730.e7 PMID: 29257951  

mTOR: The Alpha and Omega of Autophagy Regulation

Olivia C. McKee-Muir and Ryan C. Russell

Book Chapter: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Science. 2017 pg231-250

Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC*, Russell RC*, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. PMID: 25567907  *equal contribution


Autophagy regulation by nutrient signaling.
Russell RC, Yuan HX,Guan KL.
Cell Research. 2013 Dec. 17 Review. PMID:24343578

Regulation of PIK3C3/Vps34 complexes by mTOR in nutrient stress-induced autophagy.
Yuan H, Russell RC, Guan KL. 
Autophagy. 2013 Sep 5;9(12). PMID:24013218

ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. 
Russell RC, Tian Y, Yuan H, Park, HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. 
Nature Cell Biology.  2013 Jul;15( 7):741-50 PMID:23685627

Amino acid signaling upstream of mTOR. 
Jewell JL, Russell RC, Guan KL.  
Nat Rev Mol Cell Biol. 2013 Jan 30. Review. PMID:23361334

Differential Regulation of Distinct VPS34 complexes by AMPK in Nutrient Stress and Autophagy.
Kim J, Kim YC, Fang C, Russell RC, KimJH, Fan W, Liu R, Zhong Q, Guan KL. 
Cell. Jan 201317;152(1-2):290-303. PMID:23332761

YAP mediates crosstalk between the Hippo and TOR pathways by suppressing PTEN via miR-29.
Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo F, Guan KL 
Nature Cell Biology. 2012 Dec;14(12):1322-9. PMID:23143395

An emerging role for TOR signaling in mammalian tissue and stem cell physiology. 
Russell RC, Fang C, Guan KL. 
Development. 2011 Aug;138(16):3343-56. Review. PMID:21791526


Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.

Russell RC,  Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL,Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M.

Nat Med. 2011 Jun 19;17(7):845-53. PMID: 21685897

The Russell Lab

Russell lab ottawa autophagy Ryan


ULK1 beclin vhl

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