Identification of organelle-specific autophagy regulators from tandem CRISPR screens

Losier TT, King KE, Rousseaux MWC, Russell RC

J Cell Biol. 2025 Oct; 224(10):e202405138; PMID: 40838896

 

Salmonella Typhimurium exploits the reticulophagy/ERphagy receptor RETREG1 to promote infection

Gatica D, Alsaadi R, Russell RC

Autophagy. 2025 Aug; 27:1-3; PMID: 40872994

 

ALY688 Attenuates Iron-Induced ER Stress and Insulin Resistance via Activation of ER-Phagy

Nguyen K, Tang J, Gatica D, Russell RC, Sung HK, Sweeney G.

Diabetes. 2025 Aug 4:db250405; PMID: 40758485

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Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

Akuma M, Kim M, Zhu C, Wiljer E, Gaudreau-Lapierre A, Patterson LD, Egevad L, Tanguay S, Trinkle-Mulcahy L, Stanford WL, Riazalhosseini Y, Russell RC

Cell Death Dis. 2025 Apr; 16(1):307; PMID: 40240354

 

The ER-phagy receptor FAM134B is targeted by Salmonella Typhimurium to promote infection

Gatica D, Alsaadi RM, El Hamra R, Li B, Mueller R, Miyazaki M, Sun Q, Sad S, Russell RC

Nat Commun. 2025 Mar; 16(1):2923; PMID: 40133256

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The multifaceted role of autophagy in cancer

​Russell RC, Guan KL

EMBO J. 2022 Jul; 41(13):e110031; PMID: 35535466

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Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis

Hajjar S, Nathan N, Joseph J, Mottawea W, Ariana A, Pyatibrat S, Harper ME, Alain T, Blais A, Russell RC, Sad S.

Cell Death Differ. 2022 Mar; 29(3):585-599; PMID: 34588632

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Regulation of Autophagy Enzymes by Nutrient Signaling

King KE, Losier TT, Russell RC

Autophagy Enzymes by Nutrient Signaling. Trends Biochem Sci. 2021 Aug; 46(8):687-700; PMID: 33593593

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An antibody for analysis of autophagy induction

Tian WS, Alsaadi RM, Guo ZH, Kalinina A, Carrier M, Tremblay ME, Lacoste B, Lagace D & Russell RC 

Nature Methods; 2020 Feb; 17(2):232-239; PMID: 31768061

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Iron overload inhibits late stage autophagic flux leading to insulin resistance

Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G

EMBO Rep. 2019 Oct 4; 20(10):e47911; PMID: 31441223

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ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant

Alsaadi RM, Losier TT, Tian WS, Jackson A, Guo ZH, Rubinsztein DC, Russell RC

EMBO reports. 2019 May 24; e46885; PMID: 31267703

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AMPK promotes xenophagy through priming of autophagic kinases upon detection of bacterial outer membrane vesicles

Losier TT, Akuma M, McKee-Muir OC, LeBlond ND, Alsaadi RM, Suk YJ, Guo ZH, Reshke R, Sad S, Campbell-Valois FX, Gibbings DJ, Fullerton MD, Russell RC

Cell Rep. 2019 Feb 19;26(8):2150-2165. PMID: 30784596

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mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington's disease.

Abd-Elrahman KS, Hamilton A, Hutchinson SR, Liu F, Russell RC, Ferguson SSG.

Science Signaling. 2017 Dec 19;10(510). PMID: 29259100  

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Bacterial outer membrane vesicles trigger pre-activation of a xenophagic response via AMPK

Losier TT, Russell RC 

Autophagy. 2019; Aug; 15(8):1489-1491; PMID: 31107135

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Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.

Guo H, Chitiprolu M, Roncevic L, Javalet C, Hemming FJ, Trung MT, Meng L, Latreille E, Tanese de Souza C, McCulloch D, Baldwin RM, Auer R, Côté J, Russell RC, Sadoul R, Gibbings D.

Developmental Cell. 2017 Dec 18;43(6):716-730.e7 PMID: 29257951  

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mTOR: The Alpha and Omega of Autophagy Regulation

Olivia C. McKee-Muir and Ryan C. Russell

Book Chapter: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging Science. 2017 pg231-250

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Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC*, Russell RC*, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. PMID: 25567907  *equal contribution

 

Autophagy regulation by nutrient signaling.
Russell RC, Yuan HX,Guan KL.
Cell Research. 2013 Dec. 17 Review. PMID:24343578

Regulation of PIK3C3/Vps34 complexes by mTOR in nutrient stress-induced autophagy.
Yuan H, Russell RC, Guan KL. 
Autophagy. 2013 Sep 5;9(12). PMID:24013218

ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. 
Russell RC, Tian Y, Yuan H, Park, HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. 
Nature Cell Biology.  2013 Jul;15( 7):741-50 PMID:23685627

Amino acid signaling upstream of mTOR. 
Jewell JL, Russell RC, Guan KL.  
Nat Rev Mol Cell Biol. 2013 Jan 30. Review. PMID:23361334

Differential Regulation of Distinct VPS34 complexes by AMPK in Nutrient Stress and Autophagy.
Kim J, Kim YC, Fang C, Russell RC, KimJH, Fan W, Liu R, Zhong Q, Guan KL. 
Cell. Jan 201317;152(1-2):290-303. PMID:23332761

YAP mediates crosstalk between the Hippo and TOR pathways by suppressing PTEN via miR-29.
Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo F, Guan KL 
Nature Cell Biology. 2012 Dec;14(12):1322-9. PMID:23143395

An emerging role for TOR signaling in mammalian tissue and stem cell physiology. 
Russell RC, Fang C, Guan KL. 
Development. 2011 Aug;138(16):3343-56. Review. PMID:21791526

 

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.

Russell RC,  Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL,Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M.

Nat Med. 2011 Jun 19;17(7):845-53. PMID: 21685897